The contemporary view of the fundamental role of time in physics generally ignores its most obvious characteric, namely its flow. Studies in the foundations of relativistic mechanics during the past decade have shown that the dynamical evolution of a system can be treated in a manifestly covariant way, in terms of the solution of a system of canonical Hamilton type equations, by considering the space-time coordinates and momenta ofevents as its fundamental description. The evolution of the events, as functions of (...) a universal invariant world, or historical, time, traces out the world lines that represent the phenomena (e.g., particles) which are observed in the laboratory. The positions in time of each of the events, i.e., the time of their potential detection, are, in this framework, controlled by this universal parameter τ, the time at which they are generated (and may proceed in the positive or negative sense). We find that the notion of thestate of a system requires generalization; at any given τ, it involves information about the system at timest(τ) ≠ τ. The correlation of what may be measured att(τ) with what is generated at τ is necessarily quite rigid, and is related covariantly to the spacelike correlations found in interference experiments. We find, furthermore, that interaction with Maxwell electromagnetism leads back to a static picture of the world, with no real evolution. As a consequence of this result, and the requirement of gauge invariance for the quantum mechanical evolution equation, we conclude that electromagnetism is described by a pre-Maxwell field, whose τ-integral (or asymptotic behavior as τ → ∞) may be identified with the Maxwell field. We therefore consider the world of events in space time, interacting through τ-dependent pre-Maxwell fields, as far as electrodynamics is concerned, as the objective dynamical reality. Our perception of the world, through laboratory detectors and our eyes, are based onintegration over τ over intervals sufficiently large to obtain an aposteriori description of the phenomena which coincides with the Maxwell theory. Fundamental notions, such as the conservation of charge, rest on this construction. The decomposition of the common notion of time into two essentially different aspects, one associated with an unvarying flow, and the second with direct observation subject to dynamical modification, has profound philosophical consequences, of which we are able to explore here only a few. (shrink)

The heme‐containing cytochromes P‐450 are a ubiquitous family of monooxygenase isozymes responsible for the oxidative metabolism of a wide variety of endogenous as well as exogenous compounds. Many of the compounds metabolized by this enzyme system are effectively detoxified and converted to derivatives more easily eliminated from the organism. However, some compounds can be activated to reactive species capable of eliciting a cascade of toxic lesions, including cancer. Since its discovery nearly 30 years ago, the cytochrome P‐450 enzyme system has (...) received a great deal of attention, particularly in the areas of their mechanisms of metabolism, range of substrate specificity, the purification and characterization of the multiple isozymes and, more recently, the regulation of expression of specific forms. This review will discuss current notions concerning the expression of at least one cytochrome P‐450 isozyme and future directions that should lead to a more complete understanding of cytochrome P‐450 gene expression in general, particularly as it impacts upon biochemical pharmacology. (shrink)

Professor Plant has presented a briefer treatment of Hegel’s philosophical development than did H. S. Harris in Towards the Sunlight, and a considerably more historical, epistemological and metaphysical treatment than is presented in Pelcynski’s Hegel; Political Philosophy and not so exhaustive an account of the political and social philosophy as appears in Avineri’s Hegel’s Philosophy of the Modern State. These four books taken together testify to the importance of Hegel on the contemporary philosophic scene. Plant’s volume is perhaps the best (...) in that it pulls together the various philosophical, political, and social strains in brief compass, for he demonstrates quite convincingly, as did Avineri and Harris, that the political and metaphysical writings of Hegel are closely interconnected and that the interpretation of art and religion flow from his considered interpretation of his contemporary cultural situation. Plant, with Marx, Engels, Kierkegaard, Baur, Feuerbach et al. and against Findlay and Bergman, argues that there is a Christian theological residue in Hegel’s system, but surprisingly, the fruit of the system is clarification not mystification. Only with that residue is the system and totality really explicable. An altogether welcome book.—R.L.P. (shrink)

This survey of the history of Protestant thought in the nineteenth century is founded upon two major methodological principles. The first is the hard-nosed avoidance of the national history approach. In spite of the continuity in certain nations of specific theological traditions there is another sense in which the varying efforts of Protest theology struggled to answer the same questions. Welch chose to ignore, as far as possible, national boundaries and concentrate on what can usefully be called the "Victorian era" (...) historically or in theological parlance the period "between Schleiermacher and Ritschl." By ignoring national boundaries and linguistic divisions Welch is able to discuss Feuerbach, Emerson, Comte, Mill, Carlyle, and the Arnolds in one chapter. This brings us to the second methodological point: Welch has included a number of figures in his survey who are not academic theologians but rather literary men or philosophers, as Coleridge, Emerson, Hegel, the Arnolds, Comte, Mill, Carlyle, etc. What might be a surprise here is the inclusion of the literary types. This work, when complete will compare favorably on the period covered with E. Hirsch’s Geschichte der Neuern [[sic]] Evangelischen Theologie, in Zusammenhang mit der Algemeinen [[sic]] Bewegnungen [[sic]] des Europaischen [[sic]] Denkens. The present book can be supplemented by the author’s God and Incarnation in Midnineteenth [[sic]] Century German Theology in "A Library of Protestant Thought" which contains vital readings of Thomasius, Dorner, and Biedermann. Three points, briefly, in criticism. The treatment of Hegel’s notion of spirit in relation to religion is not quite right. Also, the treatment of Kierkegaard as a right-wing Hegelian is quite surprising after Löwith’s placing of him in the left-wing group in From Hegel to Nietzsche, pp. 110-115. Then too, one questions whether Kierkegaard should be dubbed a "theological conservative".—R. L. P. (shrink)

Gauge invariance of a manifestly covariant relativistic quantum theory with evolution according to an invariant time τ implies the existence of five gauge compensation fields, which we shall call pre-Maxwell fields. A Lagrangian which generates the equations of motion for the matter field (coinciding with the Schrödinger type quantum evolution equation) as well as equations, on a five-dimensional manifold, for the gauge fields, is written. It is shown that τ integration of the equations for the pre-Maxwell fields results in the (...) usual Maxwell equations with conserved current source. The analog of the O (3, 1) symmetry of the usual Maxwell theory is found to be O (3, 2) or O (4, 1), depending on the space-time Fourier spectrum of the field. We argue that the structure that is relevant to the description of radiation in interaction with matter evolving in a timelike sense is that of O (3, 2). The noncovariant form of the field equations is given; there are two fields of electric type and one (divergenceless) magnetic type field. The Noether currents are studied, and some remarks are made on second quantization. (shrink)

Professor Crites comes to his task with deep personal sympathy for and philosophic commitment to each of the protagonists in his volume. The subject of Crites’ work is not the tension of faith and history with which we are familiar in the works of Strauss, Baur, Feuerbach, Renan, and M. Arnold, but rather the tension of Christianity and culture. Crites chooses for his departure the notion and analogy of "domesticity," the accommodation, or lack thereof, of the gospel and the world. (...) With a fairness that is singularly unique among Hegelian critics of Kierkegaard, Crites argues that the issue between Kierkegaard and Hegel was the problem of the positivity of the Christian religion. For Hegel, the development of the notion of Christianity as the absolute religion solved the problem raised by the problem of positivity and Lessing’s essay "On the Proof of the Power and the Spirit." For Kierkegaard such a solution was a sellout, for it eliminated faith. Crites argues well the logic of both Kierkegaard’s and Hegel’s positions. Though the author has a few judicious things to say about Kierkegaard’s epistemology, his treatment would have profited by a more extended analysis of the epistemology of both Hegel and Kierkegaard, and by some indications regarding the importance and use of the modal categories in his author’s appraisal of both faith and history—R. L. P. (shrink)

The volume contains new translations of the introduction and preface to the second edition of The Essence of Christianity and Principles of the Philosophy of the Future. This comprises about one-half of the book. The remainder is Hanfi’s fifty-page introduction and translations of "Towards a Critique of Hegel’s Philosophy," "The Beginning of Philosophy," "The Necessity of a Reform of Philosophy," "Preliminary Theses on the Reform of Philosophy," and "Fragments Concerning the Characteristics of My Philosophical Development." The translations are quite readable. (...) Hanfi’s introduction refers to the relation of Feuerbach to Marx in the first and third sections while the second is given over to a survey of Feuerbach’s development and thought. Another aspect, and one of the most suggestive, is at the end of the first section where Hanfi attempts to show how Feuerbach’s anthropology relates to Heidegger’s Daseinsanalytik. One of the most interesting sections of Feuerbach’s text is "On the beginning of Philosophy," for Kierkegaard, in the context of fathering another philosophy of a very different kind, came upon some of the same criticisms of Hegel’s philosophy. This translation, along with those of Essence of Christianity, and the more recent The Essence of Religion, The Essence of Faith According to Luther, and the book by Kamenka, The Philosophy of Ludwig Feuerbach, bespeak a renewed interest in the essential Feuerbach.—R.L.P. (shrink)

Thought experiments analogous to those discussed by Landau and Peierls are studied in the framework of a manifestly covariant relativistic quantum theory. It is shown that momentum and energy can be arbitrarily well defined, and that the drifts induced by measurement in the positions and times of occurrence of events remain within the (stable) spread of the wave packet in space-time. The structure of the Newton-Wigner position operator is studied in this framework, and it is shown that an analogous time (...) operator can be constructed which satisfies the canonical commutation relation with the energy E but does not commute (due to the presence of a time drift term) with the momentum p. The resulting commutation relation is used as a mathematical basis for the derivation of the Landau-Peierls relation Δt Δp≳ħ/c. (shrink)

These two volumes complete the topical selections from Kierkegaard’s papers. Volume 3 covers L-R. Volume 4 covers S-Z. The entries are arranged chronologically within the topic. The forthcoming Volumes 5 and 6 will carry the autobiographical material. Volume 7 will contain a complete set of indexes and cross references. This is quite an expansion of the five volumes projected in the Hongs’ preface to Volume 1. English students will gain a full volume of selections and a much expanded cross reference (...) and index. (shrink)

A great deal can be learned about this book by considering the author’s dedication: "to the memory of Paul Tillich who showed me where to look and to Walter Kaufmann who showed me how to see." This book is an ambitious effort to show the continuity and themes of nineteenth and early twentieth century continental philosophy. Tillich taught Schacht that in that fruitful era lie the roots of many of our philosophical and theological problems, i.e., where to look. Yet, many (...) of the judgments about this period are informed by the interpretation already familiar from the writings of Walter Kaufmann. This is not to suggest that this book is a rehash of the sometimes confused and inaccurate interpretations of Kaufmann. No, Schacht is his own man and as fully capable of making his own mistakes as correcting some of Kaufmann’s. (shrink)

Pompa’s book is a welcome addition to the sparse English literature on Vico, and it will be of interest not only to philosophers but to historians, anthropologists, and other social scientists. Vico is written and developed as a guide to the final version of the New Science which is surely one of the most obscure books ever written. This is the first book in English which takes as its aim the exposition of the New Science. The other English books, ranging (...) from Flint’s Vico in 1891 to Tagliacozzo and White’s Giambattista Vico: An International Symposium contained either a general survey of ideas, as in Flint, or a wide collection of background materials and analytic, historical, or comparative studies, as in Tagliacozzo and White. A. R. Caponigri in Time and Idea expressed perhaps the historically and philosophically most controversial thesis: that Vico had attempted to temporalize and historicize the Platonic forms in his concept of the "ideal eternal history.". (shrink)

Escalation of commitment causes people to continue a failing course of action. We study the role of construal level in such escalation of commitment. Consistent with the widely held view of construal level as a primed effect, we employed a commonly used prime for manipulating this construct in a laboratory experiment. Our findings revealed that the prime failed to produce statistically significant differences in construal level, which was measured using the Behavior Identification Form. Furthermore, there was no effect of the (...) prime on escalation of commitment, or on constructs that have previously been linked to construal level such as the perceived importance of feasibility considerations relative to desirability considerations, and the number of pros and cons that subjects can think of.Interestingly, however, subjects’ actual construal level scores on the BIF were found to significantly affect escalation. Specifically, our findings show that people with a low construal level are less willing to continue a failing project. This relation is mediated by the perceived importance of the feasibility of the project relative to its desirability. For people with a low construal level, the perceived importance of feasibility relative to desirability is higher, which in turn makes escalation of commitment less likely.Our findings are consistent with prior research suggesting that priming construal level may not always be effective. Thus, while construal level has typically been regarded as a state-like variable that can be primed, in this study, we show that construal level may also be considered as a trait. (shrink)

This book ranges over a number of problems in contemporary political science. Ostensibly about Marx and Burke, Aristotle and the behaviorists also figure in the development. One of the major difficulties of the book is the forced presence of Aristotle and the absence of Hegel. "Burke and Marx being in the Aristotelian tradition, considered it absurd to speak of man as anything but a social or political animal—a zoon politikon...". This sentence is probably correct, but it is ad hoc, for, (...) on this point, Hegel is Marx’s teacher—not Aristotle. There are numerous such references, and thus, as a revisionist view in the history of ideas, the book seems at points strained and at others inaccurate. There is a level of generality at which one can say that Burke, Aristotle, and Marx occupy a common position, and that is the level at which this book is written, viz., a very general generality. One is simply stunned by the overcoming of differences, the omission of distinctions. To suggest that Hegel is a Rationalist is to stretch the language of philosophy to meaninglessness. Repeated again is the simplicities about thesis, antithesis, synthesis, cloppity, clop. Perhaps this is enough about the shortcomings of this book. (shrink)

The dynamical equations of relativistic quantum mechanics prescribe the motion of wave packets for sets of events which trace out the world lines of the interacting particles. Electromagnetic theory suggests thatparticle world line densities be constructed from concatenation of event wave packets. These sequences are realized in terms of conserved probability currents. We show that these conserved currents provide a consistent particle and antiparticle interpretation for the asymptotic states in scattering processes. The relation between current conservation and unitarity is used (...) to establish relations between pair production and annihilation amplitudes and scattering. The discrete symmetriesC, T, P are studied and it is shown that no Dirac sea (for fermions where such a construction is possible, or bosons where it is not) is required for consistency of the theory. These currents, furthermore, represent the discrete symmetries in a way consistent with their interpretation as particle currents. (shrink)

This book is not a generalized essay on Hegel’s philosophy of history as the title seems to promise. It is rather an excellent exposition and interpretation of some of the main doctrines and assumptions of Hegel about the varieties of historical writing, mechanism and teleology, contingency and necessity. It also contains a discussion of the relation of Hegel to the covering law model of explanation. The first chapter is primarily an exposition and exegesis of Hegel’s discernment of the varieties of (...) historical writing in the long introduction to the Lectures. Although this section is generally successful, one of the burdens of Wilkins’ argument is that Hegel is not an a priori thinker, yet Hegel argues that the state is a necessary precondition to people having a history. Groups without a state lie "outside his plan." That such groups may be beyond his plan is appropriate, but that they can have no history needs to be critically evaluated in light of anthropological studies. A second difficulty with the exegesis centers around the almost complete neglect by Wilkins of the idea of providence in the Lectures and the notion of Christian religion. One can wonder whether a proper understanding of Hegel’s philosophy of history is complete without due consideration of both aspects. (shrink)

BackgroundLarge-scale, centralized data repositories are playing a critical and unprecedented role in fostering innovative health research, leading to new opportunities as well as dilemmas for the medical sciences. Uncovering the reasons as to why citizens do or do not contribute to such repositories, for example, to population-based biobanks, is therefore crucial. We investigated and compared the views of existing participants and non-participants on contributing to large-scale, centralized health research data repositories with those of ex-participants regarding the decision to end their (...) participation. This comparison could yield new insights into motives of participation and non-participation, in particular the behavioural change of withdrawal.MethodsWe conducted 36 in-depth interviews with ex-participants, participants, and non-participants of a three-generation, population-based biobank in the Netherlands. The interviews focused on the respondents’ decision-making processes relating to their participation in a large-scale, centralized repository for health research data.ResultsThe decision of participants and non-participants to contribute to the biobank was motivated by a desire to help others. Whereas participants perceived only benefits relating to their participation and were unconcerned about potential risks, non-participants and ex-participants raised concerns about the threat of large-scale, centralized public data repositories and public institutes, such as social exclusion or commercialization. Our analysis of ex-participants’ perceptions suggests that intrapersonal characteristics, such as levels of trust in society, participation conceived as a social norm, and basic societal values account for differences between participants and non-participants.ConclusionsOur findings indicate the fluidity of motives centring on helping others in decisions to participate in large-scale, centralized health research data repositories. Efforts to improve participation should focus on enhancing the trustworthiness of such data repositories and developing layered strategies for communication with participants and with the public. Accordingly, personalized approaches for recruiting participants and transmitting information along with appropriate regulatory frameworks are required, which have important implications for current data management and informed consent procedures. (shrink)

In recent times, a previously unchallenged and longstanding communis opinio concerning the extant manuscript tradition of Valerius Flaccus' Argonautica has been shattered by Prof. W.-W. Ehlers in his revelation that the fifteenth-century Laurentianus plut. 39.38, L, written by the Florentine scholar, Niccolò Niccoli, is independent of the much exalted oldest witness, Vaticanus Latinus 3277, V, copied in Fulda in the second quarter of the ninth century. With equally silent subservience to the hazardous and now discredited principle, vetustissimus et optimus, second (...) place in the tradition had commonly been given to a manuscript of similar age to that of V, namely S, discovered in 1416 at the monastery of St. Gall by three humanist scholars, Poggio Bracciolini, Cencio Rustici and Bartolomeo da Montepulciano, and subsequently lost, except through reconstruction from six extant fifteenth-century apographa, each instantly recognizable from the fact that they contain only 1.1–4.317. Between V and S, however, as Ehlers and others before him have argued, a common exemplar, a, must be deduced to exist. (shrink)

This paper argues that professionals who make boundary-related decisions should be guided by relationship-based practice. In our roles as service users and professionals, drawing from our lived experiences of professional relationships, we argue we need to move away from distance-based practice. This includes understanding the boundary stories and narratives that exist for all of us – including the people we support, other professionals, as well as the organisations and systems within which we work. When we are dealing with professional boundary (...) issues, we should centre relationship-building skills that are central to many other aspects of our work. Skills that foster relationships at all levels – between professionals, service users, and services – need to be revalued. Our final recommendation is to create, develop, and foster safer spaces within and outside of organisations, as well as inter-professionally, for the discussion and exploration of boundary-related issues and practice. We are interested in hearing from those with experiences of being marginalised by boundaries so that they can inform a reshaping of our collective ideas around boundary related practices. To foster relationship-based practices in organisations, we have outlined several recommendations here; however, we recognize that these do not go far enough, and that collective action is needed to inform systemic change. (shrink)

This article presents an overview ofregulations, guidelines and societal debates ineight member states of the EC about a)embryonic and fetal tissue transplantation(EFTT), and b) the use of human embryonic stemcells (hES cells) for research into celltherapy, including `therapeutic' cloning. Thereappears to be a broad acceptance of EFTT inthese countries. In most countries guidance hasbeen developed. There is a `strong' consensusabout some of the central conditions for `goodclinical practice' regarding EFTT.International differences concern, amongstothers, some of the informed consent issuesinvolved, and the (...) questions whether anintermediary organisation is necessary, whetherthe methods of abortion may be influenced bythe possible use of EFT, and whether EFTTshould only be used for the experimentaltreatment of rare disorders. The potential useof hES cells for research into cell therapy hasgiven a new impetus to the debate about (human)embryo research. The therapeutic prospects withregard to the retrieval and research use of hEScells appear to function as a catalyst for theintroduction of less restrictive regulationsconcerning research with spare embryos, atleast in some European countries. It remains tobe seen whether the prospect of treatingpatients suffering from serious disorders withtransplants produced by therapeutic cloningwill decrease the societal and moral resistanceto allowing the generation of embryos for`instrumental' use. (shrink)

At the beginning of the twentieth century in the Russian-speaking philosophical space philosophical projects emerged which brought ontology and gnoseology closer together. One can observe this process, for example, in the philosophical doctrines of the Russian intuitivists Nikolay Lossky and Semyon Frank. I demonstrate that the emergence of these doctrines and the development of their onto-gnoseological categorial apparatus were mainly connected with the criticism of the Neo-Kantian theory of cognition and the possibility of transcendent knowledge as such. The main sources (...) of my study are The Intuitive Basis of Knowledge and The World as an Organic Whole by N. O. Lossky and The Object of Knowledge and The Unknowable by S. L. Frank. My investigation makes it possible to treat Lossky’s categorial framework as the representation of a system of levels of the universe each of which is characterised by two aspects: the ontological, i.e. it is part of the unity of the world, and the gnoseological, i.e. it has an independent cognitive significance. Frank considers categories to be an organic part of the ontological proof of intuitivism. A common trend in the construction of categorial schemes by Lossky and Frank is their striving to combine gnoseological and ontological descriptions of categories. The key difference is the way an onto-gnoseological system as a whole is justified. In revealing the contradictions in Lossky’s conception, I proceed from the critical remarks of S. A. Askoldov, pointing out that these contradictions stem from an absolutisation of intuition in cognition, the renunciation of the idea of gnoseological transcendence, incompleteness of the theory of immanence and discordance between onto-gnoseological categories. Askoldov’s critical comments clarify the substantive features of Lossky’s theory and the essence of the transformations carried out in Frank’s absolute ideal-realism. (shrink)

Representatives from eight European countries compared the legal, ethical and professional settings within which decision making for neonates takes place. When it comes to limiting treatment there is general agreement across all countries that overly aggressive treatment is to be discouraged. Nevertheless, strong emphasis has been placed on the need for compassionate care even where cure is not possible. Where a child will die irrespective of medical intervention, there is widespread acceptance of the practice of limiting aggressive treatment or alleviating (...) suffering even if death may be hastened as a result. Where the infant could be saved but the future outlook is bleak there is more debate, but only two countries have tested the courts with such cases. When it comes to the active intentional ending of life, the legal position is standard across Europe; it is prohibited. However, recognising those intractable situations where death may be lingering and unpleasant, Dutch paediatricians have reported that they do sometimes assist babies to die with parental consent. Two cases have been tried through the courts and recent official recommendations have set out standards by which such actions may be assessed. (shrink)

We used computer simulations to study the possible role of the dispersion of cellular coupling, refractoriness or both, in the mechanisms underlying cardiac arrhythmias. Local ischemia was first assumed to induce cell to cell dispersion of the coupling resistance (Case 1), refractory period (Case 2), or both of them (Case 3). Our numerical experiments based on the van Capelle and Durrer model showed that vortices could not be induced by cell to cell variations. With cellular properties dispersed in a patchy (...) way within the ischemic zone, a single activation wave could give rise to abnormal activities. This demonstrates the stability of the wave front under small inhomogeneities. Probabilities of reentry, estimated for the three cases cited above showed that a severe alteration of the coupling resistance may be an important factor in the genesis of reentry. Moreover, use of isochronal maps revealed that vortices were both stable and sustained with an alteration of the coupling alone or combined with a reduction of the action potential duration. Conversely, simulations with reduction of the refractoriness alone, inducing only transient patterns, could exhibit functionally determined reentries. (shrink)